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.Inflammatory and oxidative damage in free and immobilized T lymphocytes.
The impairment of cellular immune function, particularly that of T lymphocytes, is a hallmark of chronic infection, autoimmunity, and tumorigenesis. This is thought to result from autoimmune injury and the persistent and constitutive generation of free radicals. Since free radical damage to molecules is irreversible, the capability of immune function and T-cell-mediated immunity to natural death in response to antigenic challenge is reduced or lost in infected or tumor-bearing individuals. T-cell immunity to tumor cells may also be diminished by this mechanism. Attempts to prevent free radical damage to lymphocytes have included both dietary antioxidants and drugs that limit oxidation of cellular constituents. Not only is it unknown whether prevention of oxidative damage to immune cells can actually enhance T-cell immunity, it is not known whether immune responses to pathogens can be modulated by this mechanism. Since T lymphocytes are intimately associated with other cells such as macrophages in vivo, we propose that oxidized macromolecules such as lipoproteins that are generated during macrophage activation also alter T-cell responses. Thus, interactions between cells of the immune system or between macrophages and T cells may themselves be profoundly altered by oxidant stress. To test this hypothesis, we first compared the relative susceptibility of free and immobilized T cells to free radical damage. We found that free T cells were significantly more sensitive to oxidative stress than immobilized T cells. As an extension of this work, we tested the hypothesis that T cells in vivo are also more sensitive to free radical damage when not anchored to other cells, and that production of lipid peroxidation products by macrophages can alter T-cell responses. Immunization and challenge of mice with T cells that had been exposed to either lipopolysaccharide or to a major histocompatibility complex-restricted antigen failed to elicit a major immune response. These results suggest that lipids generated during macrophage activation may serve as a modulator of immune function and potentially play a role in human conditions such as acquired immune deficiency syndrome.
god, the one I am going to be discussing about today, is the most widely known of all the recorded false gods. Look at the languages in that pic below, and realize that they are all derived from Sanskrit, and all are spoken in India and its dependant countries such as Nepal, Bangladesh, Sri Lanka, Pakistan etc.
false god, the one I am going to be discussing about today, is the most widely known of all the recorded false gods. Look at the languages in that pic below, and realize that they are all derived from Sanskrit, and all are spoken in India and its dependant countries such as Nepal, Bangladesh, Sri Lanka, Pakistan etc.
The middle path: Offer Prayers As Appropriate For The Circumstances And To The Best Of Your Knowledge, Know That You Are Able To Make Mistakes. The only person who knows whether you are asking the right thing or the wrong thing is God himself.
It is not easy to know how to pray correctly without studying and learning from a bona fide guru. Unfortunately, most people do not know how to pray.
You need a guru to teach you how to pray correctly. Learn the proper way to conduct prayers and remember that you will never attain nirvana in a day. It is said that attaining nirvana in a day is like not getting a sound sleep for a month.
Since nirvana is attained by giving up the desire to attain, it is not attained by the mere asking of it, but it is attained by surrendering, of one’s self and of one’s previous efforts.
Satyam Shivam Sundaram
the true God, the Supreme God is the Creator God, with a capital “C”. And the God who created the universe, Lord Krishna and Rama, is also the Supreme Lord.
The word satyam means truth. A truth means what is without any doubt, not a doubt and a doubt is a falsehood.
Shivam means the Supreme God. There is only one Supreme God, Lord Krishna, Lord Rama and Lord Mahavira.
So when we pray to Lord Krishna, or to Lord Rama, or to Lord Mahavira, we are really praying to the one, the Supreme God, and not just to Krishna or to Rama or to Mahavira.
It is important to know that the Supreme Lord is not simply an entity. He is not a person, or a jivatma, or a soul. He is not a creation, he is not just an effect. He is not a mark or a sign, He is not a friend or a foe.
He is not just the Ultimate Truth, He is the Ultimate Truth. The Ultimate Truth is not just what is one, or two, or three, or four, it is not even three or
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