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web page 1 tv show xbox 360Drosha is an RNase III enzyme that processes nascent pre-miRNAs to pre-miRNA intermediates to prevent a premature termination of miRNA biogenesis. Under steady state conditions, Drosha-mediated processing of primary (pri)-miRNA occurs in the nucleus. However, the cellular location of Drosha-mediated pre-miRNA processing under conditions of stress, such as infection with viruses, remains unknown. In the present study, we demonstrate that endogenous Drosha processes a fraction of pri-miRNA transcripts derived from nuclei of virus-infected cells. This nuclear Drosha-mediated process relies on a robust RNAi-dependent degradation pathway and does not require the core components of the RNAi machinery. Consistent with these findings, the levels of nuclear-localized Drosha were significantly reduced in cells upon infection with a dsRNA virus, whereas Drosha localized primarily to nuclei of cells upon treatment with dsRNA. These results indicate a novel antiviral response induced by Drosha that could represent an important mechanism in controlling infection with viruses.
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title: “Troubleshooting”
lastmodified: ‘2017-06-03’
redirect_from:
– /Troubleshooting/
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Troubleshooting
===============
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About
Xfinity Lifetime
Xfinity is a pay TV home service provider that has been running since 1996. Xfinity can be found throughout the country, as well as overseas. Xfinity offers a variety of cable services, including the ability to record television for a set number of days on Xfinity On Demand. Xfinity On Demand contains many television shows that can be streamed at no additional cost. However, each viewing session must be purchased via a local activation code in an activation code. You can compare Xfinity TV to other home services providers on their website.
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